In general, there is no significant difference in performance between classes and prototypes in JavaScript. Both approaches are optimized by modern JavaScript engines, and the difference in performance is negligible. However, there are some cases where one approach may perform better than the other.
For example, if you need to create a large number of objects that share the same properties and methods, prototypes can be more memory-efficient since they allow objects to share the same prototype. On the other hand, classes can be more readable and easier to reason about for some developers, which can improve maintainability and reduce the likelihood of bugs.
Ultimately, the choice between classes and prototypes in JavaScript should be based on factors such as readability, maintainability, and compatibility with existing code, rather than performance considerations.